It is unclear what causes scleroderma, which results from the overproduction of a key bodily protein called collagen, Mayo Clinic states. The tissue of these organs may become hard, causing them to work less efficiently.
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Systemic scleroderma may affect the skin as well as internal organs. It can present itself as areas of hardened skin. In localized scleroderma the changes are usually found in only a few places on the skin and muscles. There are two major forms of Scleroderma: localized scleroderma and systemic scleroderma. However, the National Scleroderma Foundation states that an estimated 300,000 Americans have the disease. have the disease, mostly women between the ages of 30 and 50. The American College of Rheumatology states that around 75,000 to 100,000 people in the U.S. It is not contagious or cancerous.Īside from its effect on the skin, scleroderma can also cause inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and more.Įstimates on prevalence vary.
It is generally classed as an autoimmune disease, meaning the body's immune system attacks healthy cells. Scleroderma is a disease that causes the hardening and tightening of the skin and connective tissue, according to Mayo Clinic. Saget was on the board of directors for the Scleroderma Research Foundation for over a decade and had hosted their events for around 25 years. "It is incredibly painful to have a loved one experience a condition like this. She had to move to Los Angeles to live with my parents because she needed so much help. "She got treatment, but it was just treating her symptoms with drugs like prednisone and cortisone. She was 44 when she was diagnosed with systemic scleroderma. Saget told the National Institutes of Health's MedlinePlus magazine in 2019: "My sister, Gay Saget, was a school teacher near Philadelphia. 42% of New York's Hospitalized COVID Patients Admitted for Other Reasons.Bob Saget-What the Olsen Twins, 'Full House' Cast Have Said About His Death.Bob Saget's Wife, Kelly Rizzo, and Family 'Devastated' by Comedian's Death.